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KMID : 0829220080320010009
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Korean Journal of Oral and Maxillofacial Pathology
2008 Volume.32 No. 1 p.9 ~ p.14
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(?)-epigallocatechin-3-gallate(EGCG) Use Different Pathways in Phosphorylating Akt Depending on Cell Types
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Abstract
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The major component of green tea is (-)-epigallocatechin-3-gallate(EGCG) which accounts for 5080% of catechin, representing 200300 mg in a brewed cup of green tea. EGCG has been known to possess growth inhibitory and pro-apoptotic effect on human cancer cell lines such as prostate, bladder and breast cancers. In contrast, several studies have suggested that EGCG could promote cell proliferation and/or survival instead of pro-apoptotic effect. Understanding how intracellular signaling pathways respond to EGCG may provide a clue to the difference of cell responses and basis for usefulness of EGCG as a chemopreventive and/or chemotherapeutic agent. To better understand the mechanisms responsible for the chemopreventive efficacy of EGCG, the authors tried to identify the key molecules that contributes to Akt activation and can inhibit this activation. In the present study, EGCG increased Akt phosphorylation, an activeform of Akt and negatively affect on direct upstream molecules of Akt including PTEN and EGFR, though Akt phosphorylation was increased.
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KEYWORD
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(-)-epigallocatechin-3-gallate(EGCG), Akt, PI3K, EGFR, PDK1, PTEN, Cell survival
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